MicroRNA expression in pediatric intracranial ependymomas and their potential value for tumor grading

Chromosomal anomalies and prognostic markers for intracranial and spinal ependymomas.

Ependymomas are neoplasms that can occur anywhere along the craniospinal axis. They are the third most common brain tumor in children, representing 10% of pediatric intracranial tumors, 4% of adult brain tumors, and 15% of all spinal cord tumors. As the heterogeneity of ependymomas has severely limited the prognostic value of the World Health Organization grading system, numerous studies have f...

MicroRNA and Male Infertility: A Potential for Diagnosis

Evaluation of CD133 and CD56/NCAM expression in Wilms tumor and their association with prognostic factors

Objective(s): To validate certain markers for cancer stem cell populations and their clinical importance in Wilms tumor (WT)Materials and Methods: Immunohistochemical study for CD133 and CD56/NCAM was performed on forty-six cases of WT that were diagnosed between 1999 and 2015, and the association of these markers with survival and progn...

The Current Management of Intracranial Ependymomas in Children

E are relatively rare neuroepithelial tumors and account for 3-7% of all central nervous system (CNS) tumors. Among pediatric CNS tumors, ependymomas are the third most common intracranial tumor (6-14%) after juvenile pilocytic astrocytomas and primitive neuroectodermal tumors. The incidence in children is reported to be six times that in adults. Fifty percent of them occur under the age of fiv...

Evaluation of MicroRNA-99a and MicroRNA-205 Expression Levels in Bladder Cancer

Bladder cancer is the second most common cancer in the genitourinary tract, showing often recurrence and progresse into invasive states. Epigenetic changes, such as microRNA alteration are involved in bladder cancer tumorigenesis through a variety of signaling pathways. The epigenetic state depends on geographic and lifestyle conditions. The aim of this study was to investigate the expression l...